Jessica Thomes Pepin, MD

Gynecologic Oncology

Primary Location

Maplewood Cancer Center
1580 Beam Avenue
Maplewood, Minnesota 55109
(651) 779-7978

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Board Certification

Board Certified in Obstetrics & Gynecology
Board Eligible in Gynecologic Oncology


American Board of Obstetricians & Gynecologists
Society of Gynecologic Oncologists
American Association of Cancer Research

Areas of Special Interest

  • Robotic assisted surgery and minimally invasive techniques
  • Complex vulvar surgical procedures
  • Complex abdominal surgical care for gynecologic processes including cancer
  • Chemotherapeutic care for gynecologic malignancies

Philosophy of Care

Cancer care begins with the patient. My compassionate, patient-driven focus is to provide comprehensive, state-of-the-art treatment of the highest quality nature. My goals are to utilize the latest evidence-based medicine, directed in a multi-disciplinary fashion to fully optimize each individual patient’s oncologic outcome. At Minnesota Oncology, we offer the ability to participate in multiple clinical trials. This offers not only the ability for enrollment of patients in need, but potentially enhances the treatment for our patients of the future. 


Medical School

University of Minnesota Medical School, Minneapolis, MN


Obstetrics & Gynecology, Indiana University School of Medicine, Indianapolis, IN


Gynecologic Oncology, Indiana University School of Medicine, Indianapolis, IN

Academic Honors & Professional Achievements

  • Recipient of the Galloway Fellowship at Memorial Sloan-Kettering Cancer Center, New York, NY
  • Awarded the best research project and presentation for the graduating residency class of 2013
  • Awarded the 4.0 Club Award for Teaching all 4 years of residency
  • Inducted into the Gold Humanism Honor Society (GHHS) in 2011


Dr. Thomes Pepin presented her research on Current trends in operative morbidity of groin lymph node dissections in vulvar cancer at the IGCS Biennial Conference in Vancouver, Canada and poster presentations at several conferences including the Society for Gynecologic Oncologists, the Western Association for Gynecologic Oncologists and the American Association of Cancer Research. She has written and co-authored several book chapters on translational advances in gynecologic cancer and the perioperative surgical care for gynecologic oncology patients. 


Jessica Thomes Pepin, MD


Nothing gives me greater pleasure than coming home at the end of a busy work day to my sweet family. My husband and I were overjoyed to be offered the opportunity to move back to our home state, so that we could provide medical care to the best of our abilities to the wonderful people of Minnesota.

My husband and I love attending Twins games, Vikings games and other professional and amateur sporting events. We also enjoy spending time with our families in greater Minnesota.

I personally enjoy attending musicals, the opera and choral performances. I love the ability to relief stress through exercise, specifically running. I love anything to do with water sports and swimming.