Minnesota Oncology

Leukemia News

SYNRIBO® Approved for use in Chronic Myeloid Leukemia (February 21, 2014)

The U.S. Food and Drug Administration (FDA) has granted full approval of SYNRIBO® (omacetaxine mepesuccinate) for injection. SYNRIBO is indicated for adult patients with chronic phase (CP +0.28%, news) or accelerated phase (AP) chronic myeloid leukemia... Continue Reading

Ibrutinib approved by FDA for Chronic Lymphocytic Leukemia (February 12, 2014)

On February 12, 2014, the U. S. Food and Drug Administration granted accelerated approval to ibrutinib (IMBRUVICA, Pharmacyclics, Inc.) for the treatment of patients with chronic lymphocytic leukemia (CLL) who have received at least one prior therapy. ... Continue Reading

Chronic Lymphocytic Leukemia Phase III Trial Stopped After Data Shows Clear Advantage for Imbruvica (January 29, 2014)

An Independent Data Monitoring Committee (IDMC) recommended that a phase 3 study be stopped early after data indicated that Imbruvica™ (ibrutinib) provided a clear survival advantage compared with the control drug in patients with chronic lymphocytic... Continue Reading

Link Between Allergies and Blood Cancers in Women (January 1, 2014)

Researchers hare found a link between airborne allergies and the risk of blood cancers in women, according to the results of a study published in the American Journal of Hematology. Cancer research has increasingly become focused on the immune system... Continue Reading

Mylotarg Reduces Risk of Relapse in Childhood AML (December 20, 2013)

Mylotarg® (gemtuzumab ozogamicin)—a drug that was withdrawn from the market in 2010 because of uncertain benefit and safety concerns—reduces the risk of relapse in children and young adults with acute myeloid leukemia (AML). These results were presented... Continue Reading

Reduced-Intensity Stem Cell Transplant Minimizes Effects on Mental Functioning (December 20, 2013)

In contrast to full-intensity stem cell transplants, reduced-intensity stem-cell transplants appear to have little effect on cognitive function. These results were presented at the 2013 Annual Meeting of the American Society of Hematology. Stem cells... Continue Reading

Gazyva/Chlorambucil Improves Outcomes in Older CLL Patients with Other Health Problems (December 16, 2013)

Among older people with chronic lymphocytic leukemia (CLL) and other health problems, initial treatment with Gazyva® (obinutuzumab) and chlorambucil was more effective than treatment with Rituxan® (rituximab) and chlorambucil. These results were presented... Continue Reading

Gazyva Approved for CLL (November 22, 2013)

The U.S. Food and Drug Administration (FDA) has approved Gazyva™ (obinutuzumab) for use in combination with chlorambucil to treat patients with previously untreated chronic lymphocytic leukemia (CLL). Chronic lymphocytic leukemia (CLL) is the most common... Continue Reading

Busulfex Superior to Total Body Irradiation in AML in First Remission (November 1, 2013)

Myeloablative conditioning with cyclophosphamide and Busulfex® (intravenous busulfan) was associated with better leukemia-free and overall survival than conditioning with cyclosphosphamide and total-body irradiation (TBI) in patients with acute myeloid... Continue Reading

End-of-Life Care Remains Aggressive, Despite Patient Wishes (September 16, 2013)

Although most patients with advanced cancer prefer hospice or palliative care that minimizes symptoms, many continue to receive aggressive treatment during their final weeks and months of life. In fact, elderly patients with advanced cancer often receive... Continue Reading

Latest Leukemia News By Stage


Acute Lymphoblastic Leukemia

Iclusig Approved for CML and ALL (January 4, 2013)

The U.S. Food and Drug Administration (FDA) has approved Iclusig™ (ponatinib) to treat adults with chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL), two rare blood and bone marrow diseases. Chronic... Continue Reading

Blinatumomab Prolongs Survival in Relapsed/Refractory Adult ALL (December 14, 2012)

Blinatumomab induces high complete remission rates and prolongs survival in adult patients with relapsed/refractory B-precursor acute lymphoblastic lymphoma (ALL), according to the results of a study presented at the 54th Annual Meeting of the American... Continue Reading

Marqibo Approved for Treatment of Philadelphia-Negative ALL (August 17, 2012)

The U.S. Food and Drug Administration (FDA) has approved Marqibo® (vincristine sulfate liposome injection) to treat adults with Philadelphia chromosome negative (Ph-) acute lymphoblastic leukemia (ALL) whose leukemia has returned or progressed following... Continue Reading

One Subset of Childhood Acute Lymphoblastic Leukemia is Best Treated with Chemotherapy (April 20, 2012)

A subset of young patients with acute lymphoblastic leukemia (ALL) who fail to achieve remission after the initial weeks of intense chemotherapy known as induction therapy appear to have better outcomes with additional chemotherapy rather than bone marrow... Continue Reading

Survival Continues to Improve Among Children and Adolescents with ALL (March 15, 2012)

Between 1990 and 2005, five-year survival for children and adolescents with acute lymphoblastic leukemia (ALL) increased from 83.7 percent to 90.4 percent. These results were published in the Journal of Clinical Oncology. ALL—a fast-growing cancer of... Continue Reading

More Acute Lymphoblastic Leukemia

Acute Myeloid Leukemia

Mylotarg Reduces Risk of Relapse in Childhood AML (December 20, 2013)

Mylotarg® (gemtuzumab ozogamicin)—a drug that was withdrawn from the market in 2010 because of uncertain benefit and safety concerns—reduces the risk of relapse in children and young adults with acute myeloid leukemia (AML). These results were presented... Continue Reading

Busulfex Superior to Total Body Irradiation in AML in First Remission (November 1, 2013)

Myeloablative conditioning with cyclophosphamide and Busulfex® (intravenous busulfan) was associated with better leukemia-free and overall survival than conditioning with cyclosphosphamide and total-body irradiation (TBI) in patients with acute myeloid... Continue Reading

CPX-351 Highly Active in Older Patients with AML (January 18, 2013)

CPX-351 is highly active in all patient subgroups and produced the greatest benefits in response rate and reduction in 60-day mortality compared to standard therapy in older patients with secondary acute myeloid leukemia and adverse cytogenetics, according... Continue Reading

Combination of Revlimid and Vidaza Beneficial in Untreated Elderly Patients with AML (January 14, 2013)

The sequential combination of Vidaza® (azacitidine) and Revlimid® (lenalidomide) shows evidence of clinical activity as initial therapy for older patients with acute myeloid leukemia, according to the results of a phase II study presented at the 54th... Continue Reading

Quizartinib Shows Promise in Treatment-Resistant AML (December 19, 2012)

The targeted agent quizartinib showed promise in the treatment of a subset of patients with treatment-resistant acute myeloid leukemia (AML), according to the results of a study presented at the 54th Annual Meeting of the American Society of Hematology... Continue Reading

More Acute Myeloid Leukemia

Acute Promyelocytic Leukemia

Many Patients with “Chemo Brain” Recover within Five Years (May 23, 2011)

A study of “chemo brain”—the foggy thinking and forgetfulness that patients may experience after chemotherapy—suggests that the condition improves substantially over time for a majority of patients. For some patients, however, symptoms may persist... Continue Reading

More Acute Promyelocytic Leukemia

Adult Acute Lymphoblastic Leukemia

Many Patients with “Chemo Brain” Recover within Five Years (May 23, 2011)

A study of “chemo brain”—the foggy thinking and forgetfulness that patients may experience after chemotherapy—suggests that the condition improves substantially over time for a majority of patients. For some patients, however, symptoms may persist... Continue Reading

More Adult Acute Lymphoblastic Leukemia

Childhood Acute Lymphoblastic Leukemia

One Subset of Childhood Acute Lymphoblastic Leukemia is Best Treated with Chemotherapy (April 20, 2012)

A subset of young patients with acute lymphoblastic leukemia (ALL) who fail to achieve remission after the initial weeks of intense chemotherapy known as induction therapy appear to have better outcomes with additional chemotherapy rather than bone marrow... Continue Reading

Many Patients with “Chemo Brain” Recover within Five Years (May 23, 2011)

A study of “chemo brain”—the foggy thinking and forgetfulness that patients may experience after chemotherapy—suggests that the condition improves substantially over time for a majority of patients. For some patients, however, symptoms may persist... Continue Reading

More Childhood Acute Lymphoblastic Leukemia

Chronic Lymphoblastic Leukemia

Gazyva/Chlorambucil Improves Outcomes in Older CLL Patients with Other Health Problems (December 16, 2013)

Among older people with chronic lymphocytic leukemia (CLL) and other health problems, initial treatment with Gazyva® (obinutuzumab) and chlorambucil was more effective than treatment with Rituxan® (rituximab) and chlorambucil. These results were presented... Continue Reading

Ibrutinib Active In Untreated, Relapsed and Unresponsive CLL (June 3, 2013)

The drug ibrutinib was well tolerated and highly effective in patients with untreated, relapsed and unresponsive chronic lymphocytic leukemia—leading to large reductions in tumor burden, according to the results of a study presented at the American... Continue Reading

Lymphoma Patients and Transplant Recipients at Higher Risk of Melanoma (October 11, 2012)

Individuals with lymphoma or those who have undergone organ transplants are far more likely than the average person to develop—and die from—melanoma, according to the results of a review published in Mayo Clinic Proceedings. Melanoma is a potentially... Continue Reading

Combination of Campath and Fludarabine Provides Benefit in CLL (February 16, 2012)

Among people with previously treated, relapsed or refractory chronic lymphocytic leukemia (CLL), treatment with a combination of Campath® (alemtuzumab) and fludarabine results in better outcomes than treatment with fludarabine alone. These results were... Continue Reading

Many Patients with “Chemo Brain” Recover within Five Years (May 23, 2011)

A study of “chemo brain”—the foggy thinking and forgetfulness that patients may experience after chemotherapy—suggests that the condition improves substantially over time for a majority of patients. For some patients, however, symptoms may persist... Continue Reading

More Chronic Lymphoblastic Leukemia

Chronic Lymphocytic Leukemia

Ibrutinib approved by FDA for Chronic Lymphocytic Leukemia (February 12, 2014)

On February 12, 2014, the U. S. Food and Drug Administration granted accelerated approval to ibrutinib (IMBRUVICA, Pharmacyclics, Inc.) for the treatment of patients with chronic lymphocytic leukemia (CLL) who have received at least one prior therapy. ... Continue Reading

Chronic Lymphocytic Leukemia Phase III Trial Stopped After Data Shows Clear Advantage for Imbruvica (January 29, 2014)

An Independent Data Monitoring Committee (IDMC) recommended that a phase 3 study be stopped early after data indicated that Imbruvica™ (ibrutinib) provided a clear survival advantage compared with the control drug in patients with chronic lymphocytic... Continue Reading

Gazyva Approved for CLL (November 22, 2013)

The U.S. Food and Drug Administration (FDA) has approved Gazyva™ (obinutuzumab) for use in combination with chlorambucil to treat patients with previously untreated chronic lymphocytic leukemia (CLL). Chronic lymphocytic leukemia (CLL) is the most common... Continue Reading

Ibrutinib Highly Active in Patients with Chronic Lymphocytic Leukemia with 17p Deletion (July 18, 2013)

The targeted agent ibrutinib produced rapid and durable control of disease in both treatment-naïve and relapsed/refractory patients with 17p deletion chronic lymphocytic leukemia, according to the results of a study presented at the 12th International... Continue Reading

Many Patients with “Chemo Brain” Recover within Five Years (May 23, 2011)

A study of “chemo brain”—the foggy thinking and forgetfulness that patients may experience after chemotherapy—suggests that the condition improves substantially over time for a majority of patients. For some patients, however, symptoms may persist... Continue Reading

More Chronic Lymphocytic Leukemia

Chronic Myeloid Leukemia

SYNRIBO® Approved for use in Chronic Myeloid Leukemia (February 21, 2014)

The U.S. Food and Drug Administration (FDA) has granted full approval of SYNRIBO® (omacetaxine mepesuccinate) for injection. SYNRIBO is indicated for adult patients with chronic phase (CP +0.28%, news) or accelerated phase (AP) chronic myeloid leukemia... Continue Reading

Iclusig Approved for CML and ALL (January 4, 2013)

The U.S. Food and Drug Administration (FDA) has approved Iclusig™ (ponatinib) to treat adults with chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL), two rare blood and bone marrow diseases. Chronic... Continue Reading

Tasigna Superior to Gleevec for Philadelphia Chromosome-Positive CML (December 21, 2012)

Tasigna® (nilotinib) is superior to Gleevec® (imatinib) for the treatment of patients with Philadelphia chromosome-positive chronic myeloid leukemia (CML), according to the results of two studies presented at the 54th Annual Meeting of the American... Continue Reading

Synribo Approved for CML (November 8, 2012)

The U.S. Food and Drug Administration today approved Synribo (omacetaxine mepesuccinate) to treat adults with chronic myelogenous leukemia (CML), a blood and bone marrow disease that usually affects older adults. Each year in the United States, approximately... Continue Reading

Bosulif Approved for CML (September 26, 2012)

The U.S. Food and Drug Administration (FDA) has approved Bosulif® (bosutinib) to treat chronic myelogenous leukemia (CML), a blood and bone marrow disease that usually affects older adults. The drug is intended for patients with chronic, accelerated... Continue Reading

More Chronic Myeloid Leukemia

Hairy Cell Leukemia

Many Patients with “Chemo Brain” Recover within Five Years (May 23, 2011)

A study of “chemo brain”—the foggy thinking and forgetfulness that patients may experience after chemotherapy—suggests that the condition improves substantially over time for a majority of patients. For some patients, however, symptoms may persist... Continue Reading

More Hairy Cell Leukemia

Screening/Prevention Leukemia

Link Between Allergies and Blood Cancers in Women (January 1, 2014)

Researchers hare found a link between airborne allergies and the risk of blood cancers in women, according to the results of a study published in the American Journal of Hematology. Cancer research has increasingly become focused on the immune system... Continue Reading

Childhood CT Scans Linked to Leukemia and Brain Cancer Later in Life (June 20, 2012)

Children and young adults who undergo multiple computed tomography (CT) scans have an increased risk of leukemia and brain tumors in the decade following their first scan, according to the results of a study published in The Lancet. CT scans are a common... Continue Reading

Aspirin Continues to Look Promising for Cancer Prevention (March 26, 2012)

A combined analysis of 51 randomized trials found that daily aspirin use reduces the risk of new cancer diagnoses as well as the risk of cancer death. These results were published in The Lancet. A growing body of evidence suggests that aspirin may reduce... Continue Reading

Greater Cancer Risk Among Taller Women (July 28, 2011)

Taller women may have an increased risk of developing certain cancers. Overall, cancer risk increases by 16% for every 4-inch increase in height. These findings were recently reported in Lancet Oncology. Greater insight into height and cancer risk may... Continue Reading

Stay on Top of Your Family History of Cancer (July 15, 2011)

People who are at high risk of cancer as a result of their family history may be advised to undergo earlier or more intensive cancer screening. Because family history of cancer can change over time, it’s important to update this information periodically... Continue Reading

More Screening/Prevention Leukemia