Drug Dictionary


Zadaxin™

(Other name for: recombinant thymosin)

zalcitabine

A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zalcitabine preferentially inhibits the gamma form of DNA polymerase present in tumor cell mitochondria, resulting in the inhibition of tumor cell mitochondrial DNA replication and tumor cell death. Check for active clinical trials using this agent. (NCI Thesaurus)

Zaltrap

(Other name for: ziv-aflibercept)

zalutumumab

A fully human IgG1 monoclonal antibody directed against the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. Zalutumumab selectively binds to the EGFR receptor and blocks receptor binding of EGF and transforming growth factor-alpha (TGF-a), which results in the disruption of EGFR-mediated cell signaling, cell growth inhibition and apoptosis in EGFR-expressing tumor cells. In addition, this agent triggers antibody dependent cellular cytotoxicity (ADCC) in EGFR-expressing cells. EGFR is a cell surface receptor tyrosine kinase, overexpressed on many cancer cells. Check for active clinical trials using this agent. (NCI Thesaurus)

Zalypsis

(Other name for: PM00104)

Zanaflex

(Other name for: tizanidine hydrochloride)

zanamivir

A sialic acid-analogue neuraminidase inhibitor with antiviral activity. Administered into the respiratory tract by aerosol inhalation, zanamivir selectively binds to and inhibits influenza A and B virus neuraminidase-mediated cleavage of sialic acid residues in host cell membrane-bound glycoprotein receptors for influenza viruses, preventing the release of progeny viruses from host cell surfaces and, so, further viral replication. Check for active clinical trials using this agent. (NCI Thesaurus)

zanolimumab

A human IgG1k monoclonal antibody against the CD4 receptor on T lymphocytes, with potential antineoplastic and immunosuppressing activities. Zanolimumab targets and binds to the CD4 receptor on certain T cells thereby preventing the interaction between the CD4 receptor and the major histocompatibility complex class II molecule. This prevents activation of CD4-positive T cells. In addition, zanolimumab is able to induce an antibody-dependent cellular cytotoxicity (ADCC) response against CD4-expressing tumor cells. CD4, a receptor located on a subset of T-lymphocytes, is upregulated in T-cell lymphomas. Check for active clinical trials using this agent. (NCI Thesaurus)

Zanosar

(Other name for: streptozocin)

Zarnestra

(Other name for: tipifarnib)

Zarontin

(Other name for: ethosuximide)

Zarxio

(Other name for: filgrastim)

ZD6126

A water-soluble phosphate prodrug of N-acetylcolchinol with potential antiangiogenesis and antineoplastic activities. ZD6126 is converted in vivo into N-acetylcolchinol. N-acetylcolchinol binds to and destabilizes the tubulin cytoskeleton of endothelial cells in tumor blood vessels, which may result in tumor endothelial cel apoptosis, the selective occlusion of tumor blood vessels, cessation of tumor blood flow, and tumor necrosis. Check for active clinical trials using this agent. (NCI Thesaurus)

Zelboraf

(Other name for: vemurafenib)

Zemplar

(Other name for: paricalcitol)

Zemuron

(Other name for: rocuronium bromide)

Zenapax

(Other name for: daclizumab)

Z-endoxifen hydrochloride

The hydrochloride salt and the z (cis-) stereoisomer of endoxifen with potential antineoplastic activity. Endoxifen, the active metabolite of tamoxifen, competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA and thus reducing DNA synthesis. Unlike tamoxifen, however, which relies on CYP2D6 activity for its conversion to the active metabolite endoxifen, the direct administration of endoxifen bypasses the CYP2D6 route. As CYP2D6 activity can vary widely among individuals due to genetic CYP2D6 polymorphisms, endoxifen is therefore theoretically more potent and more uniform in its bioavailability across patient populations. Check for active clinical trials using this agent. (NCI Thesaurus)

Zenpep

(Other name for: pancrelipase)

Zerit

(Other name for: stavudine)

Zestril

(Other name for: lisinopril)

Zetia

(Other name for: ezetimibe)

Zevalin

(Other name for: ibritumomab tiuxetan)

Zevalin

(Other name for: yttrium Y 90 ibritumomab tiuxetan)

Zeven

(Other name for: Hsp90 inhibitor debio 0932)

zhongyao fufang

A combination formula consisting of two or more unknown Traditional Chinese Medicine (TCM) ingredients, with potential anti-osteoporotic activity. Upon oral administration, this particular formula of zhongyao fufang may promote increased bone strength and density. Check for active clinical trials using this agent. (NCI Thesaurus)

Ziagen

(Other name for: abacavir sulfate)

zibotentan

An orally available selective antagonist of the endothelin-A (ET-A) receptor with potential antineoplastic activity. Zibotentan binds selectively to the ET-A receptor, thereby inhibiting endothelin-mediated mechanisms that promote tumor cell proliferation. Check for active clinical trials using this agent. (NCI Thesaurus)

ziconotide

A synthetic, nonopiod, twenty-five amino acid polybasic peptide analogue of an omega-conotoxin derived from the marine snail Conus magus with analgesic activity. Ziconotide appears to block neuronal N-type voltage-sensitive calcium channels (NCCB), inhibiting transmission from pain-sensing primary nociceptors. This agent may exhibit significant analgesic activity in refractory pain. Check for active clinical trials using this agent. (NCI Thesaurus)

zidovudine

A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines. Check for active clinical trials using this agent. (NCI Thesaurus)

zileuton

A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma. Check for active clinical trials using this agent. (NCI Thesaurus)

zinc gluconate

A nutritional supplement containing the zinc salt form of gluconic acid for the purpose of providing zinc. As an essential trace element, zinc is of key importance in many biological processes, acts as an antioxidant and strengthens the immune system. Although the mechanism of action is not completely known, zinc supplementation may be used to increase immunity against viruses or may interfere with the replication of certain viruses, such as the human papillomavirus (HPV). Check for active clinical trials using this agent. (NCI Thesaurus)

zinc oxide/aluminum starch octenylsuccinate/glycyrrhetinic phytosome/vitamin E/botanical extracts-based skin protectant paste

A paste containing multiple skin protectants with anti-oxidant, skin protecting, moisturizing, anti-erythema and anti-inflammatory activities. The paste includes zinc oxide, aluminum starch octenylsuccinate, lanolin, allantoin, chamomile and sweet almond oil, rice bran oil, shea butter, dimethicone (polymerized siloxane), petrolatum, vitamin E, phytosome of glycyrrhetinic acid and botanical extracts derived from Calendula officinalis, Malva sylvestris and Tilia tomentosa. Upon application, this paste provides a physical barrier on the skin and may help protect, soothe and moisturize the skin as well as restore skin softness, integrity and elasticity. When this paste is applied to the perineum area, it may help prevent radiation-induced dermatitis. Check for active clinical trials using this agent. (NCI Thesaurus)

zinc sulfate

A salt of the essential trace metal zinc. Zinc is involved in tissue repair and is an important constituent of some proteins, including those involved in taste and smell. Zinc sulfate supplementation may prevent radiation-induced aguesia. Check for active clinical trials using this agent. (NCI Thesaurus)

Zinecard

(Other name for: dexrazoxane hydrochloride)

zinostatin

An enediyne antineoplastic antibiotic hybrid containing an aminoglycoside chromophore. Zinostatin is isolated from the bacterium Streptomyces carzinostaticus. The aminoglycoside component of zinostatin intercalates into DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-strand breaks in DNA and apoptosis. Check for active clinical trials using this agent. (NCI Thesaurus)

Zipan

(Other name for: promethazine hydrochloride)

zirconium Zr 89 bevacizumab

A radioimmunoconjugate comprised of the recombinant humanized monoclonal antibody bevacizumab labeled with the radioisotope zirconium Zr 89 (Zr 89) with radioisotopic activity and potential imaging use. The antibody moiety of zirconium Zr 89 bevacizumab targets and binds to the extracellular domain of the vascular endothelial growth factor receptor (VEGFR). Upon binding, the radioisotope moiety may be detected using positron emission tomography (PET), allowing the imaging and quantification of VEGFR-expressing tumor cells. VEGFR, a tyrosine kinase, is overexpressed on the cell surfaces of various tumor cell types. Check for active clinical trials using this agent. (NCI Thesaurus)

zirconium Zr 89 cetuximab

A radioimmunoconjugate comprised of the recombinant chimeric monoclonal antibody cetuximab labeled with the radioisotope zirconium Z 89 (Zr 89) with radioisotopic activity and potential imaging use. The antibody moiety of zirconium Zr 89 cetuximab binds to the extracellular domain of the epidermal growth factor receptor (EGFR). Upon binding, the radioisotope moiety may be detected using positron emission tomography (PET), allowing the imaging and quantification of EGFR-expressing tumor cells. EGFR is a tyrosine kinase that may be overexpressed on the cell surfaces of various tumor cell types. Check for active clinical trials using this agent. (NCI Thesaurus)

zirconium Zr 89 desferrioxamine B monoclonal antibody huJ591

A radioimmunoconjugate comprised of the recombinant humanized monoclonal antibody J591 against prostate-specific membrane antigen (PSMA) conjugated to chelator desferrioxamine B (DFO-B) and labeled with the radioisotope zirconium Zr 89 with potential imaging property used in positron emission tomography (PET) imaging. Upon administration of zirconium Zr 89 desferrioxamine B monoclonal antibody huJ591, the antibody moiety binds to the extracellular domain of PSMA, and the radioisotope moiety may be detected using PET, thereby allowing the imaging and quantification of PSMA-expressing tumor cells. PSMA, or folate hydrolase is a cell surface peptidase highly expressed by malignant prostate epithelial cells and vascular endothelial cells of numerous solid tumor malignancies. In addition, upon PET imaging this agent provides high tumor:background tissue ratios. Check for active clinical trials using this agent.

Next Page